Panhandle Plains Vacations from $209

Book a Hotel + Flight or Car together to unlock savings

Photo by Courtesy of Visit Lubbock
  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Panhandle Plains Vacation

Panhandle Plains's rugged landscapes and rich traditions are just the beginning of the great things this destination has to offer travelers. Get the best out of your retreat by pulling together your own Panhandle Plains vacation package. Your trip to Panhandle Plains wouldn't be complete without getting to some of its most well-known cities, starting with Amarillo. Two of the top attractions here include Cadillac Ranch and Wonderland Amusement Park. Lubbock is another favorite with Panhandle Plains travelers. Visitors to this exciting destination enjoy Buddy Holly Center and United Supermarkets Arena. Expedia has everything you need when it comes to organizing your Panhandle Plains vacation. From accommodations and flights, to car rentals and activities, we know how to create a travel experience like no other.

The Latest Panhandle Plains vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Fort Worth / Fossil Creek
Element Dallas Downtown East
Hilton Dallas/Plano Granite Park
Hilton Dallas Lincoln Centre by the Galleria
Wyndham DFW Airport
Don't see what you're looking for?
See all available trips from Columbus to Panhandle Plains
View all trips

Where to stay in Panhandle Plains

Find the best Panhandle Plains areas and neighborhoods for the activities you enjoy most. Learn more about Panhandle Plains

Discover the most popular places to visit in Panhandle Plains

Panhandle Plains Hotel Deals

The Cactus Cove Inn and Suites

The Cactus Cove Inn and Suites

2 out of 5
2501 E Interstate Dr, Amarillo, TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $102 total per night from Aug 8 to Aug 9
$102 total
Aug 8 - Aug 9
Total includes taxes and fees
7.8/10 Good! (1,858 reviews)
"The entire place was honestly just a dream, amazing staff, koi pond where you can feed the fish, GREAT rooms, and a beautiful restaurant right inside"

Reviewed on Aug 6, 2025

The Cactus Cove Inn and Suites
La Quinta Inn by Wyndham Amarillo Mid-City

La Quinta Inn by Wyndham Amarillo Mid-City

3 out of 5
1708 I-40 E, Amarillo, TX
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $64 total per night from Sep 2 to Sep 3
$64 total
Sep 2 - Sep 3
Total includes taxes and fees
7.2/10 Good! (1,110 reviews)
"Nice property for a motel. Room was good. No mold that we seen, smelled nice and clean. Breakfast was great, better than expected."

Reviewed on Aug 4, 2025

La Quinta Inn by Wyndham Amarillo Mid-City
Atrea Inn Amarillo

Atrea Inn Amarillo

2.5 out of 5
2035 Paramount Blvd, Amarillo, TX
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $74 total per night from Aug 10 to Aug 11
$74 total
Aug 10 - Aug 11
Total includes taxes and fees
8.4/10 Very Good! (2,079 reviews)
"It's just great"

Reviewed on Aug 3, 2025

Atrea Inn Amarillo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.